Clinical significance of the detection of serum iNOS and SOD in patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2014.22.022
- VernacularTitle:慢性乙型肝炎患者血清诱导型一氧化氮合酶和超氧化物歧化酶检测的临床意义
- Author:
Yunfeng SHEN
;
Hongbo ZHANG
;
Yao WU
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
HBV-DNA;
NO;
induced nitric oxide syntheses;
superoxide dismutase
- From:
International Journal of Laboratory Medicine
2014;(22):3055-3056,3058
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the HBV‐DNA ,ALT ,AST and NO ,iNOS ,SOD levels in serum of patients with chronic hepatitis B(CHB) .Methods 24 patients with mild CHB ,30 patients with moderate CHB ,18 patients with se‐vere CHB and 30 healthy individuals were selected and set in group A ,B ,C and D ,respectively .The serum levels of HBV‐DNA , ALT ,AST ,NO ,iNOS ,and SOD were detected by FQ‐PCR and chemical analysis respectively .Results There were significant difference in the levels of ALT ,AST ,NO ,iNOS and SOD between group D and group A ,B and C (P<0 .05) .The serum level of ALT was positive relative to the levels of NO and iNOS(r=0 .487 ,0 .521 ,P<0 .05) ,and was negative relative to the level of SOD (r= -0 .574 ,P<0 .05) .The serum level of AST was positive relative to the levels of NO and iNOS(r=0 .453 ,0 .545 ,P<0 .05) , and was negative relative to the level of SOD(r= -0 .484 ,P<0 .05) .Conclusion With the increase of ALT and AST levels ,the levels of NO and iNOS increase ,and the level of SOD decreases simultaneously in CHB patients .It is suggested hepatocellular inju‐ry .
