The efficacy and safety analysis of glucocorticoid deescalation combined antiviral therapy on severe hepatitis B
10.3969/j.issn.1671-8348.2014.33.023
- VernacularTitle:糖皮质激素降阶梯联合抗病毒治疗对早期乙型重症肝炎的阻断效果及安全性分析
- Author:
Chunlei ZHANG
;
Danxi WANG
;
Liang YIN
;
Jiali YU
;
Zhizhen JIANG
;
Jianhui NIE
- Publication Type:Journal Article
- Keywords:
glucocorticoids;
deescalation therapy;
severe hepatitis B;
early stage
- From:
Chongqing Medicine
2014;(33):4485-4486,4489
- CountryChina
- Language:Chinese
-
Abstract:
Objective Observe the efficacy and safety of glucocorticoid deescalation combined antiviral therapy on severe hepati‐tis B .Methods Forty‐nine patients with early severe hepatitis were selected and divided them into observation group(n=24) and control group (n=25) randomly .Control group were given the conventional synthetic therapy while observation group were given conventional synthetic therapy combined glucocorticoid deescalation therapy .Then compare the differences of TBIL ,ALT ,PTA be‐fore and after treatment ,and the improvement time of syndrome and death rate between two groups .Results The death rate in ob‐servation group and control group were 16 .7% and 32 .0% respectively(P<0 .05) ,the improvement time of syndrome in observa‐tion group were shorten than control group(P<0 .05) ,and there was no statistical difference in bleeding and infection rate between two groups(P>0 .05) .After the treatment ,the TBIL ,ALT ,PT were improved in both two groups(P<0 .05) .But the observation group had better improvement than control group ,the difference had statistical significance(P<0 .05) .After treatment ,the changes of HBV DNA between two groups showed no significant difference(P> 0 .05) .Conclusion Glucocorticoid deescalation therapy could decrease the death rate ,shorten the syndrome lasting time in treating severe hepatitis B .It was an effective and safety meth‐od .
