Effect of bone marrow-derived mesenchymal stem cells combined with vi-tamin E on inflammatory reaction in acute kidney injury

VernacularTitle:骨髓间充质干细胞联合维生素E对急性肾损伤炎症反应的抑制作用
Author: Lei ZHAO ; Yetong FENG ; Chao DONG ; Yulai ZHOU ; Pengfei LIU
Publication Type:Journal Article
Keywords: Bone marrow-derived mesenchymal stem cells; Vitamin E; Acute kidney injury; Inflammatory re-action
From: Chinese Journal of Pathophysiology 2014;(10):1891-1895,1901
CountryChina
Language:Chinese
Abstract: AIM: To explore the effect of bone marrow-derived mesenchymal stem cells (BMSCs) combined with vitamin E on the inflammatory reaction in acute kidney injury ( AKI) rats.METHODS:Gentamicin was used to in-duce AKI and the rats were treated with BMSCs combined with vitamin E.After treatment, the rat plasma and kidney tis-sues were collected, and the expression of inflammatory factors at mRNA and protein levels was detected by real-time quan-titative PCR and ELISA.RESULTS:After the treatment with BMSCs combined with vitamin E, the inflammatory proteins were down-regulated in the plasma and the renal tissues.Compared with single treatment group, the decreases in the in-flammatory proteins were more obvious in combined treatment group.CONCLUSION: The method of BMSCs combined with vitamin E takes the anti-inflammatory effect on AKI, indicating a new and potential mode in clinical application for AKI therapy.