Epstein-Barr virus infections and clinicopathologic feature of oral, maxillofacial and neck primary malignant lymphoma in Guangxi
10.13315/j.cnki.cjcep.2014.12.016
- VernacularTitle:广西口腔颌面颈部原发性淋巴瘤 EBV感染及其临床病理特征分析
- Author:
Chunying LUO
;
Yunlong LU
;
Huiyuan LING
;
Bingchen HUANG
;
Qin HUANG
;
Huamei WEI
;
Haishan LU
;
Shixi WEI
- Publication Type:Journal Article
- Keywords:
lymphoma;
Epstein-Barr virus;
in situ hybridization;
oral and maxillofacial region
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(12):1391-1393,1397
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relation of Epstein-Barr virus ( EBV) infections and malignant lymphoma. Methods EBV-co-ded RNA ( EBER) was detected by in situ hybridization in tumor tissue of 81 cases of malignant lymphoma in oral, maxillofacial and neck regions, with analysis of the clinical pathological features. Results The detection frequencies of EBER was 44. 44%. The posi-tive detection of EBER in Hodgkin′s lymphomas was 40% and that in non-Hodgkin lymphomas was 45. 1%, including 75% in T cell lymphomas, 87. 5% in NK/T cell lymphomas and 2. 9% in B-cell lymphoma. The positive rates of EBER in T cell lymphomas and NK/T cell lymphomas were significantly higher than that in B-cell lymphoma (P<0. 05). There was a significant difference in the pos-itive rates of EBER between intra-nodal ( 17. 9%) and extra-nodal ( 58. 5%) lymphomas ( P<0. 05 ) . But there was no significant difference the positive rates of EBER between in lymphoma patients over 50 years of age and under the age of 50 patients (55. 9%) (P>0. 05). Conclusion Oral and maxillofacial and neck lymphoma is closely associated with EBV infection in Guangxi region, espe-cially, in which NK/T cell lymphoma most typically occurs in extra-nodal diffuse lymphoid tissues.
