Effect of chemotherapy on serum ABCG2 level of non-small cell lung cancer
10.3969/j.issn.1671-8348.2014.35.019
- VernacularTitle:化学治疗对NSCLC血清ABCG2水平的影响
- Author:
Daxing WANG
;
Tong XIE
;
Naiquan MAO
;
Chuantian ZUO
;
Bo ZHU
;
Qi PAN
;
Shoufeng WANG
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small cell lung;
ABCG2;
enzyme-linked immunosorbent assay;
chemotherapy
- From:
Chongqing Medicine
2014;(35):4764-4765,4768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of the serum ABCG2 level of patients with non‐small cell lung cancer(NSCLC)be‐fore and after chemotherapy ,and explore its clinical significance .Methods Venous blood specimens of 15 healthy adults and 50 pa‐tients with NSCLC were collected before and chemotherapy ,the serum ABCG2 level of these specimens were detected by ELISA . the relation between the ABCG2 level and the chemosensitivity was investigated .Results The serum ABCG2 level of patients with NSCLC before chemotherapy was significantly higher than that in healthy adults(P<0 .05);the serum ABCG2 level was not related with TNM stage in NSCLC(P<0 .05);The serum ABCG2 level of patients with NSCLC after chemotherapy was significantly high‐er than that of before(P<0 .05);in chemosensitive patients ,the different of serum ABCG2 level was not significantly before and af‐ter chemotherapy(P>0 .05);among chemoresistant patients ,the serum ABCG2 level of patients with NSCLC after chemotherapy was significantly higher than that of before(P<0 .05);the serum ABCG2 level was higher in patients with pleural effusion than the patients without pleural effusion ,but the different was not significantly(P>0 .05) .Conclusion The serum ABCG2 level of patients with NSCLC is higher than that of healthy adults ;serum ABCG2 level may become a useful indicator in predicting the effect of NSCLC chemotherapy .
