Morphological structural changes in umbilical vessels of fetus in patients with pregnancy induced hypertension
10.3969/j.issn.1671-8348.2014.36.007
- VernacularTitle:妊娠高血压综合征患者胎儿脐带血管形态结构的变化
- Author:
Zhi YANG
;
Haiyan NIU
- Publication Type:Journal Article
- Keywords:
umbilical cord;
vessel;
pregnancy induced hypertension;
morphological structure
- From:
Chongqing Medicine
2014;(36):4869-4871,4874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study morphological structural changes for different segment umbilical vessels of fetus in patients with pregnancy induced hypertension (PIH) ,and explore relationship between PIH and umbilical vessels .Methods Totally 36 umbilical cords from fetus of pregnant women without and with PIH (17 cases ,19 controls) were collected ,and take umbilical cord of placen‐tal ,middle ,and fetal segment to routine dehydration ,embedding ,section and stain .In the cases 9 women had mild preeclampsia ,6 had severe preeclampsia and 4 had eclampsia .Microscope images were obtained by digital microscope ,and lumen diameter ,wall thickness and wall‐luminal ratio of different segment umbilical vein and arteries were tested by computer image analysis software . The test results were analyzed and compared .Results From the placental end to the fetal end ,the lumen diameter and wall‐luminal ratio gradually decreased ,and wall thickness gradually increased in the umbilical vein and arteries (P<0 .05) .Compared to normal pregnant women ,the lumen diameter and wall‐luminal ratio decreased ,and wall thickness increased in patients with PIH ,and the a‐bove changes aggravated by disease severity (P<0 .05) .Conclusion PIH is associated with structural changes in the umbilical ves‐sels .These changes are more predominant in the vein than in the artery and most obvious in the fetal end .
