Association between polymorphisms of IL-1 0 genes and susceptibility of H.pylori-associated gastric cancer
10.3969/j.issn.1671-8348.2014.34.001
- VernacularTitle:IL-10基因多态性与幽门螺杆菌相关胃癌易感性的关系
- Author:
Shaoyan WU
;
Yonghong WANG
- Publication Type:Journal Article
- Keywords:
gastric neoplasms;
interleukin-10;
gene polymorphisms;
Helicobacter pylori
- From:
Chongqing Medicine
2014;(34):4561-4562,4565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between IL-10 genes and susceptibility of H.pylori-associated gastric cancer of Han population in Chongqing district.Methods 100 H.pylori-positive patients with gastric cancer(gastric cancer group)and 140 H.pylori-positive healthy people (control group)were chose in the study,PCR-RFLP method was used to detect the IL-10-592 lo-cus polymorphisms of Han population in Chongqing district.Results Comparing with control group,IL-10-592 genotype frequency distribution of gastric cancer group has statistically significance (χ2=16.36,P<0.05).Logistic regression analysis showed that gastric cancer incidence risk of people carrying with IL-10-592 A/A genotype was OR=4.37(95%CI:2.04-9.38),comparing with the subjects carrying with IL-10-592 C/C.Conclusion Polymorphism of IL-10 gene has close correlated with H.pylori-asso-ciated gastric cancer,IL-10-592 C/C might be the susceptibility gene of H.pylori-associated gastric cancer.
