Expression of annexin A1 in tissues of colorectal carcinoma and its clinical pathological significance
10.3969/j.issn.1671-8348.2014.34.016
- VernacularTitle:大肠癌组织中膜联蛋白A1的表达及其病理意义
- Author:
Baoqing WANG
;
Shiqiang ZHANG
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
annexin A1;
immunohistochemistry
- From:
Chongqing Medicine
2014;(34):4608-4609,4612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Annexin A1 proteins in colorectal cancer tissues and the relationship be-tween it and clinicopathologic features of colorectal cancer.Methods The surgical specimens from 48 cases of colorectal cancer,36 cases of adjacent tissues,15 cases of adenoma polyp were used to be examined expression of Annexin A1 immunohistochemical method.Results The positive expression rate of Annexin A1 in cancer tissue(64.6%)was significantly higher than those in adja-cent tissues(38.8%)and adenoma polyp tissues(40.0%)(P<0.05).The adjacent tissues and adenoma polyp tissues with positive Annexin A1 expression showed mild to severe atypical hyperplasia.The positive rates of Annexin A1 were significantly lower in the well-differentiated adenocarcinoma,tumor size of <5 cm,with no metastasis to lymphnodes and no invasion to surrounding tissues of colorectal cancer than those in the moderately or poorly differentiated adenocarcinoma,tumor size of ≥5 cm,with metastasis to lymphnodes and invasion in surrounding tissues(P<0.05).Conclusion The expression levels of Annexin A1 may be an important index of occurrence,progression and biological behaviors of colorectal carcinoma.
