Application of serum CysC,SAA and urinary microˉalbumin detection in early diagnosis of diabetic nephropathy
10.3969/j.issn.1673-4130.2014.24.024
- VernacularTitle:CysC、SAA和尿微量清蛋白在早期糖尿病肾病诊断中的应用
- Author:
Ling JIANG
;
Jibao QIN
;
Xiaojuan FENG
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
cystatin C;
serum amyloid A;
urinary microalbumin
- From:
International Journal of Laboratory Medicine
2014;(24):3355-3356,3359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the application value of the combination detection of serum cystatin C(CysC),serum amyloid A (SAA)and urinary microalbumin(malb)for the early diagnosis of diabetic nephropathy(DN).Methods 112 cases of diabetic melli-tus(DM)were selected and divided into the non-DN group(malb<25 mg/L)and the early DN group(malb 30-299 mg/L)according to the urinary microalbumin level.50 cases of healthy subjects were selected as the control group.The levels of serum CysC and malb were measured by immuno-scatter turbidmetry and SAA was measured by enzyme-linked immunosorbent assays(ELISA).At the same time,the biochemical indexes of GLU,Cr,HbA1C were detected too.Results The levels of CysC,SAA and malb in the DM two groups were significantly higher than those in the healthy control group with statistical differences(P <0.05 ),moreover which were increased with the renal damage aggravation;the levels in the early DN group were significantly higher than those in the non-DN group with statistical differences(P <0.05).The levels of GLU and HbA1C in the DM two groups had statistically signifi-cant differences compared with the healthy control group(P <0.05).Conclusion The levels of serum CysC and SAA in the DM pa-tients are increased with the urinary malb level increase.The combined detection of CysC,SAA and malb could increase the diagnos-tic rate of the renal damage in early DN.
