Explore the clinical value of adrenomedullin on children with acute heart failure treatment and prognosis
10.3969/j.issn.1673-4130.2014.24.030
- VernacularTitle:肾上腺髓质素对评价小儿急性心力衰竭治疗及预后的临床价值探讨
- Author:
Xiaofeng MA
;
Haiying GAO
- Publication Type:Journal Article
- Keywords:
adrenomedullin;
endothelin-1;
acute heart failure;
prognosis
- From:
International Journal of Laboratory Medicine
2014;(24):3369-3370,3372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To e xplore the clinical value of adrenomedullin on children with acute heart failure treatment and progno-sis.Methods Selected 58 cases of AHF children,40 patients with pneumonia,40 cases of children with congenital heart disease and 50 healthy children as the object,radioimmunoassay was taken to detected plasma adrenomedullin and endothelin level,and analysed correlation between AMD,ET-1 and cardiac function.Results Pneumonia complicated with heart failure group,congenital heart disease complicated with heart failure group plasma AMD,ET-1 levels were significantly higher than those in the control group, congenital heart disease group and pneumonia group (P<0.05),congenital heart disease group and pneumonia group of plasma AMD,ET-1 levels were significantly higher than those in the control group (P<0.05).Heart failure stage plasma AMD,ET-1 lev-els were significantly higher than those of early stage and recovery period (P<0.05),heart failure early stage plasma AMD,ET-1 levels were significantly higher than those of early heart failure recovery period (P<0.05).There was a significantly negative cor-relation between with AMD,EF-1 levels and CI,LVEF in AHF children (r= -0.614,-0.793,-0.618,-0.547,P<0.05);AMD mutation rate was significantly higher than that of EF-1 (P<0.05).Conclusion Plasma levels of ADM are closely relate with heart function in AHF children,through the determination of plasma ADM level can assessment treatment and the prognosis of children with AHF,and worthy of clinical application.
