Evaluation of diagnostic performance of clinical laboratory indexes in rheumatoid arthritis
10.3969/j.issn.1673-4130.2014.24.020
- VernacularTitle:类风湿关节炎相关实验室指标的诊断性能评价
- Author:
Yu HUANG
;
Tao WANG
;
Shuhui DAI
;
Chaoyang HUANG
;
Xun LI
- Publication Type:Journal Article
- Keywords:
anti-cyclic cirullinated peptide antibodies;
rheumatoid factor;
C reactive protein;
rheumatoid arthritis
- From:
International Journal of Laboratory Medicine
2014;(24):3345-3346,3349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical diagnostic significance of clinical laboratory indexes of anti-CCP,rheumatoid factor (RF),C reactive protein(CRP)and erythrocyte sedimentation rate(SR)in rheumatoid arthritis.Methods Anti-CCP,RF and CRP were quantitatively tested in 90 patients confirmed as rheumatoid arthritis(RA)and 93 patients with non-rheumatoid arthritis(non-RA)diseases by the electrochemiluminescence immunoassay(ECLIA),immunization rate scattering turbidimetry,etc.T test results were performed the statistical and comprehensive analysis by using the ROC curves.Results The levels of anti-CCP and RF had statistical differences between the RA group and the non-RA group(P <0.05 ),while there was no statistically significant differ-ences in the levels of CRP and SR(P >0.05 ).The areas under ROC curves(AUC)of anti-CCP,RF,CRP and SR were 94.0%, 84.0%,51.7% and 56.5% respectively;the sensitivity of anti-CCP and RF was 90.0% and 74.4% respectively,while the specifici-ty was 94.6% and 86% respectively;the Youden indexes were 84.6%and 60.4% respectively;the diagnostic sensitivity of CRP was only 52.2% and the diagnostic specificity of SR was only 50.5%.Conclusion Anti-CCP and RF have the good diagnostic value for RA,moreover the diagnostic performance of anti-CCP is better than RF;CRP and SR have the poor diagnostic preformance,the combination of above indexes has more clinical significance for diagnosing RA.
