Evaluation of sphingosine kinase 1 expression and its clinical significance in breast invasive ductal carcinoma

VernacularTitle:鞘氨醇激酶1蛋白在乳腺浸润性导管癌组织中的表达及其临床意义
Author: Min YI ; Rong WANG ; Lu CHEN ; Tingting SHEN ; Lianchuan SONG ; Shengzhen ZHONG
Publication Type:Journal Article
Keywords: SphK1; Breast invasive ductal carcinoma; Clinical significance; Immunohistochemistry
From: Chinese Journal of Immunology 2014;(12):1683-1685,1691
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of sphingosine kinase 1 (SphK1) and its clinical significance in breast invasive ductal carcinoma ( BIDC).Methods: We detected SphK1 expression in 58 samples of surgically resected paired BIDC and normal tumor-adjacent tissues samples by using immunohistochemistry.The correlation between SphK 1 expression and clinicopathologic features was analyzed.Results: The positive expression rate of SphK 1 in BIDC tissues was 69.0% ( 40/58 ) , while its positive expression rate in normal tumor-adjacent was 17.2% (10/58),the difference was statistical significance (χ2=31.636,P=0.000). Clinicopathological evaluation suggested that SphK 1 positive expression was associated with ER negative (χ2=4.392,P=0.036),PR negative (χ2=7.920 , P=0.005 ) , lymph node metastasis (χ2 =5.033 , P=0.025 ) and tumor stage (χ2 =7.117 , P=0.008 ) . Conclusion:The high-expression of SphK1 is correlated with the poor clinicopathological features in BIDC ,suggesting SphK1 may play a key role in development and progression of BIDC.