Comparative study between intervention transcatheter direct thrombolysis and vein thrombolysis plus anti-coagulation therapy for treating lower extremity deep venous thrombosis
10.3969/j.issn.1008-0074.2015.04
- VernacularTitle:介入导管直接溶栓与静脉溶栓并抗凝治疗下肢深静脉血栓的对比研究
- Author:
Guojian XU
- Publication Type:Journal Article
- Keywords:
Catheterization;
Thrombolytic therapy;
Venous thromboembolism
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(4):402-407
- CountryChina
- Language:English
-
Abstract:
Objective: To compare the therapeutic effect of intervention transcatheter direct thrombolysis and vein thrombolysis and anti-coagulation drugs on lower extremity deep venous thrombosis (DVT). Methods: A total of 61 patients with lower extremity DVT accorded with inclusion standards were selected. They were randomly divided into intervention transcatheter direct thrombolysis group (n=30, intervention group) and vein thrombolysis and anti-coagulation group (n=31, thrombolysis + anti-coagulation group). Patients were treated for four weeks as a course. Results: Total effective rate of intervention group was significantly higher than that of thrombolysis + anti-coagulation group (93.33% vs. 64.52%), χ2=4.987, P=0.032. There were no significant differences in hemorheology indexes between two groups before treatment, P>0.05. Compared with before treatment, after treatment, there were significant reductions in high shear whole blood viscosity, low shear whole blood viscosity, plasma viscosity and fibrinogen level in intervention group, P<0.05 all; there were significant reductions in plasma viscosity and fibrinogen level in thrombolysis + anti-coagulation group, P<0.05 both. After treatment, compared with thrombolysis + anti-coagulation group, there were significant reductions in low shear whole blood viscosity [(12.10±2.13) mPa•s vs. (11.08±1.67) mPa•s] and plasma viscosity [(1.85±0.13) mPa•s vs. (1.31±0.09) mPa•s] in intervention group, P<0.05 both. After treatment, total effective rate of vessel open up in intervention group was significantly higher than that of thrombolysis + anti-coagulation group (90.00% vs. 61.29%), χ2=4.173, P=0.047. Conclusion: For patients with acute DVT and no operation contraindications, therapeutic effect of transcatheter direct thrombolysis is more significant. It can significantly improve hemorheology and vessel open up rate, it may be recommended as the preferred in clinic.
- Full text:P020151009591283320449.doc
