Therapeutic effect of nicorandil on microvascular angina pectoris
10.3969/j.issn.1008-0074.2015.02
- VernacularTitle:尼可地尔对微血管性心绞痛的治疗效果
- Author:
Guoyong HU
;
Lina XU
- Publication Type:Journal Article
- Keywords:
Microvascular angina;
Exercise test;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(2):164-168
- CountryChina
- Language:English
-
Abstract:
Objective: To observe the therapeutic effect of nicorandil on microvascular angina pectoris (MAP). Methods: A total of 60 MAP patients were randomly divided into nicorandil group (n=30) and routine treatment group (n=30), and they were treated for 12 weeks. Onset times and duration of angina pectoris, changes of related parameters of ECG treadmill exercise test before and after treatment, and total effective rate were compared between two groups. Results: Compared with before treatment, there were significant reductions in onset times and duration of angina pectoris and maximum depression extent of ST segment (P<0.05 or <0.01) and significant increase in total exercise time (P<0.01) after treatment in both groups; compared with routine treatment group, there were significant reductions in onset times of angina pectoris [(10.3±1.6) times/week vs. (9.6±1.7) times/week] and maximum depression of ST segment [(0.8±0.3)mm vs. (0.6±0.2)mm], and significant increase in total exercise time [(7.8±1.4) min vs. (9.4±1.6) min] and total effective rate (73.3% vs. 93.3%) in nicorandil group, P<0.05 or <0.01. Conclusion: Nicorandil possesses significant therapeutic effect on microvascular angina pectoris, and it is worth further study.
- Full text:P020150619765314775865.doc
