Influence of exercise rehabilitation on heart function, and plasma levels of angiotensin Ⅱ and endothelin-1 in patients with CHF of CHD
10.3969/j.issn.1008-0074.2015.01
- VernacularTitle:运动康复对冠心病慢性心衰患者心功能,血管紧张素Ⅱ及内皮素-1水平的影响
- Author:
Xuean YAN
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Heart failure;
Rehabilitation
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(1):5-9
- CountryChina
- Language:English
-
Abstract:
Objective: To observe the therapeutic effect of exercise rehabilitation training on patients with coronary heart disease (CHD) complicated chronic heart failure (CHF). Methods: According to odd and even number, a total of 96 patients were randomly divided into rehabilitation exercise group (n=48) and routine treatment group (n=48). Rehabilitation exercise group received exercise rehabilitation training based on routine treatment for eight weeks. Changes of NYHA cardiac function class, left ventricular ejection fraction (LVEF) and 6 min walking distance (6MWD) were observed and compared between two groups before and after treatment. Enzyme linked immunosorbent assay (ELISA) was used to measure plasma levels of angiotensin Ⅱ (AngⅡ) and endothelin-1 (ET-1) in two groups before and after treatment. Results: (1) Compared with routine treatment group after eight-week treatment, there was significant improvement in NYHA cardiac function [(2.12±0.71) classes vs. (1.26±0.54) classes], and significant rise in LVEF [(38.26±6.49)% vs. (47.03±5.96)%] and 6MWD [(390.55±40.12) m vs. (501.23±44.37) m] in rehabilitation exercise group, P<0.05 or <0.01; (2) After treatment, plasma levels of AngⅡ and ET-1 significantly reduced in both groups, and those of rehabilitation exercise group were significantly lower than those of routine treatment group in patients with same NYHA cardiac function class, P<0.05 or<0.01. Conclusion：Exercise rehabilitation training can improve cardiac function, decrease plasma levels of angiotensin Ⅱ and endothelin-1 and possess high safety in patients with chronic heart failure.
- Full text:P020150303608713207029.doc
