Expressions and significance of CIP2A and VEGF in hepatocellular carcinomas
10.3760/cma.j.issn.1008-1372.2014.08.021
- VernacularTitle:肝细胞癌中CIP2A、 VEGF的表达及其临床意义
- Author:
Kai ZUO
;
Dong XUE
;
Li KONG
;
Xinjun LI
;
Tongjun ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular/pathology;
Immunohistochemistry;
Protein phosphatase 2/metabolism;
Neoplasm invasiveness;
Suppressor factors,immunologic/metabolism;
Endothelial growth factors/biosynthesis
- From:
Journal of Chinese Physician
2014;16(8):1082-1084,1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of cancerous inhibitor of protein phosphatase 2A (CIP2A) and vascular endothelial growth factor (VEGF) in hepatocellular carcinomas and their clinical significance.Methods The expressions of CIP2A and VEGF proteins were tested with immunohistochemistry in 60 cases of hepatocellular carcinomas and adjacent paracancerous tissues.Results The positive rate of CIP2A in hepatocellular carcinomas was significantly higher than adjacent paracancerous tissues (83.3％ vs 9.5％,P ＜ 0.05).Significant differences were also observed in the expression rate of VEGF between the patients with hepatocellular carcinomas and paracancerous tissues (75.0％ vs 14.3％,P ＜0.05).The expression of CIP2A in hepatocellular carcinomas was significantly positively correlated with its pathological grading,differentiation,and tumor node metastasis (TNM) stage (P ＜ 0.05).The expression of VEGF in hepatocellular carcinomas was significantly positively correlated with its pathological grading,differentiation,and TNM stage (P ＜ 0.05).Significantly positive correlation was found between expressions of CIP2A and VEGF with Spearman correlation analysis (rs =0.465,P ＜ 0.01).Conclusions The abnormal expressions of CIP2A and VEGF gene may promote tumor angiogenesis and progression of a hepatocellular carcinoma.The study supports positive regulation between expressions of CIP2A and VEGF in a hepatocellular carcinoma.
