Effects of Arkadia on TGF-β/Smad signal transduction pathway
10.3760/cma.j.issn.1673-4181.2014.04.015
- VernacularTitle:Arkadia在TGF-β/Smad信号转导通路中的作用
- Author:
Xiaoya LIU
;
Lijian CUI
;
Ruixia LIU
;
Chenghong YIN
- Publication Type:Journal Article
- Keywords:
Arkadia;
TGF-β signal transduction pathway;
Drosophila mothers against decapentaplegic
- From:
International Journal of Biomedical Engineering
2014;37(4):251-254,后插6
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-β (TGF-β) is a multifunctional protein and regulates a wide variety of cellular bio-effects,such as proliferation,differentiation,migration and apoptosis.Studies have proven that TGF-β is one of the important cytokines that promote fibrosis,and it is confirmed to be closely related to the progression of tumor.Smad signaling is the major pathway in which TGF-β fulfills its functions.These years,it has been found that E3 ubiquitin ligases Arkadia can enhance the biological effect of TGF-β signal transduction pathway through Smad signaling pathway.Therefore,it is increasingly attracting public attention.This study will summarize the effects of Arkadia on TGF-β/Smad signal transduction pathway.
