Expression levels of serum visfatin and leptin and their clinical significance in patients with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2014.27.005
- VernacularTitle:2型糖尿病患者血清内脂素和瘦素表达水平及临床意义
- Author:
Shiqiang FANG
;
Deyong KONG
;
Fen MEI
;
Zhongxin LU
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
nicotinamide phosphoribosy ltransferase;
leptin;
insulin
- From:
Chongqing Medicine
2014;(27):3565-3566,3569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of serum visfatin ,leptin and other indexes and their correlation and clinical significance in the patients with type 2 diabetes mellitus(T2DM ) .Methods Eighty-two age-matched and gender-matched cases of T2DM (T2DM group)and 71 cases of healthy subjects(health control group)were tested serum visfatin ,leptin ,insulin ,lipid and glycemia levels .Results The serum visfatin ,leptin ,triglycerides(TG) ,total cholesterol(TC) ,high-density lipoprotein choles-terol(HDL-C) and low density lipoprotein cholesterol(LDC-C) ,fasting plasma glucose ,fasting insulin(FINS) ,homeostasis model assessment of insulin resistance(OMA-IR) ,2 h FPG ,2 h FINS had statistically significant differences between the T 2DM group and the health control group(P< 0 .05);the stepwise regression analysis showed that visfatin were positively correlated with BMI , FINS ,HOMA-IR ,TC ,TG ,LDL-C (P<0 .05)and negatively correlated with HDL-C(P<0 .05);leptin were positively correlated with BMI ,FINS ,HOMA-IR(P<0 .05) .Conclusion Serum visfatin and leptin in the T2DM patients are hither than those in the healthy subjects and closely related with blood lipid ,blood glucose and insulin ,which may become the new diagnostic indexes of T2DM .
