Effects of citrate dialysate on Th17 in peripheral blood of patients with chronic renal failure
- VernacularTitle:枸橼酸盐透析液对慢性肾衰患者外周血Th17的影响
- Author:
Jun GAO
;
Li HAO
;
Shengyin MA
- Publication Type:Journal Article
- Keywords:
citrate;
bicarbonate;
chronic renal failure;
hemodialysis
- From:
Acta Universitatis Medicinalis Anhui
2014;(10):1436-1439,1440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of maintenance hemodialysis with citrate-bicarbonate dialysate on Th17 in peripheral blood of patients with chronic renal failure (CRF). Methods The CRF patients (n=57) with main-tenance hemodialysis for more than three months as well as free-active infection were selected and divided into two groups randomly, which were treated by citrate-bicarbonate dialysate and ordinary carbonate dialysate for mainte-nance dialysis in 12 month, respectively. The levels of interleulin-17 (IL-17) and percentages of Th17 subgroup in peripheral blood were detected by enzyme-linked immunosorbent assay and flow cytometer, respectively. ResultsThe levels of IL-17 and percentages of Th17 subgroup in patients treated with citrate-bicarbonate dialysate for more than six months were significantly lower than those treated with ordinary carbonate dialysate. Moreover, incidences of adverse reactions in group of citrate bicarbonate dialysate were lower than those of common carbonate dialysate group. Conclusion The pro-inflammatory effects of maintenance hemodialysis with citrate-bicarbonate dialysate on the patients are lower than those of ordinary carbonate dialysate. Citrate-bicarbonate dialysate causes the reduction of inflammatory state, and is worthy of being popularized in clinic.
