The smoking cessation effect on pulmonary function of chronic obstructive pulmonary disease and its mechanism
- VernacularTitle:戒烟对慢性阻塞性肺疾病肺功能的影响及机制探讨
- Author:
Qianqian ZHOU
;
Xiaoling XU
;
Daqing XIA
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
genetic polymorphism;
superoxide dismutase;
lung function;
FEV1/FVC％
- From:
Acta Universitatis Medicinalis Anhui
2014;(9):1317-1319,1320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the smoking cessation intervention impact on lung with genetic polymorphism of SOD3. The aim is to further reveal the importance of smoking cessation intervention on early COPD patients. Meth-ods 60 COPD patients with smoking cessation intervention and 40 COPD patients without intervention ( the control group) were enrolled in this study. Limosis peripheral blood was taken and whole blood corpuscle genomic DNA was extracted. The genetic polymorphism of SOD3 genes was determined by ligase detection reaction and polymerase chain reaction ( LDR-PCR) and serum SOD3 concentration was measured using ELISA. Lung function between the two groups before and after intervention were detected by microspirometry. Results ①The FEV1% and the FEV1/FVC% were increased after 3 and 6 months intervention in smoking cessation group(P<0.05). But there was no significant difference ( P <0.05 ) between 3 and 6 months. ② Different SOD3 genotypes have no significant on COPD pulmonary function after intervention(P>0.05). ③The serum of SOD3 concentration of COPD intervention group and the control have no significance after intervention ( P>0.05 ) . ④ The serum of SOD3 concentration a-bout CC and CG/GG genotype in COPD intervention group have no significance after 3 and 6 months intervention ( P>0.05 ) . Conclusion Smoking cessation interventions for patients with COPD pulmonary function improves significance in short-term. But different SOD3 genotypes have no effect on lung function after intervention. Smoking cessation intervention has no effect on in serum SOD3 concentration of COPD patients, and has no relationship be-tween the expression of SOD3 genetype.
