Development on neurodegenerative disorder modeling with induced pluripotent stem cells

VernacularTitle:应用诱导多能干细胞构建体外神经退行性疾病模型的研究进展
Author: Yinzhong MA ; Guanhua DU
Publication Type:Journal Article
Keywords: iPSCs; disease model; neurodegenerative disorder; HTS; HCS; cell differentiation
From: Chinese Pharmacological Bulletin 2014;(9):1185-1188,1189
CountryChina
Language:Chinese
Abstract: Remarkable advances in cellular reprogramming have made it possible to investigate relevant cell populations derived from induced pluripotent stem cells ( iPSCs ) of patients. Be-cause many diseases have its specific genetic information, using the cells to convert into iPSCs can build up a set of genetic pro-file of diseases. The iPSCs which contain the genetic contribution of the donor can be expanded and differentiated into cells of the affected lineages to show aberrant phenotypes in culture. To date, over fifty such disease models have been reported, and while the field is young and hurdles remain, we can foresee the huge potential of it in drug screening. Recent studies using iP-SCs to model various neurogenetic disorders are summarized. Compared to the traditional methods, we analyze the future de-velopment of iPSC based disease models and its past application on high-throughput screening ( HTS) and high-content screening ( HCS) .