Research progress on the relationship between sleep disorders and Alzheimer's disease
10.3969/j.issn.1001-1978.2014.09.002
- VernacularTitle:睡眠障碍与阿尔采末病相关性研究进展
- Author:
Jingwen DONG
;
Yuan SHI
;
Jianjun ZHANG
- Publication Type:Journal Article
- Keywords:
sleep disorders;
Alzheimer's disease;
amyloid;
cir-cadian rhythm;
drug therapy;
drug effects
- From:
Chinese Pharmacological Bulletin
2014;(9):1189-1192,1193
- CountryChina
- Language:Chinese
-
Abstract:
Sleep disorders are common diseases with various dys-function during sleep-wake process, including difficulty falling or staying asleep, falling asleep at inappropriate times, excessive total sleep time, or abnormal behaviors associated with sleep. Sleep disorders can lead to the deposition of amyloid beta protein ( Aβ) by affecting the normal metabolism of amyloid beta protein in the brain. Patients with Alzheimer’s disease ( AD) often suffer from sleep disorders, and its pathology always results in more se-vere sleep disorders, which leads to a risk of cognitive impair-ment and hypofunction. Sleep disorders could interact closely with AD, forming a positive feedback loop, which causes serious damage to the body health. This review summarized the current research about sleep disorder in the onset of AD and the current status of medication.
