Effect of famitinib malate on adverse reactions by radiotherapy and chemotherapy in treatment of advanced nasopharyngeal carcinoma

VernacularTitle:苹果酸法米替尼联合同步放化疗治疗晚期鼻咽癌不良反应观察及护理
Author: Yan HE ; Yuying FAN ; Yuan HAN ; Qiuyan CHEN ; Linmin CHEN ; Haiqiang MAI
Publication Type:Journal Article
Keywords: nasopharyngeal carcinoma; famitinib malate; radiotherapy and chemotherapy; adverse reactions; nursing
From: Modern Clinical Nursing 2014;(8):27-30,31
CountryChina
Language:Chinese
Abstract: Objective To investigate effect of famitinib malate on adverse reactions by radiotherapy and chemotherapy in treatment of advanced nasopharyngeal carcinoma and the nursing strategies.Methods From November 2011 to December 2013, 20 cases of advanced nasopharyngeal carcinoma in our hospital were treated with famitinib malate combined with radiotherapy and chemotherapy.During the treatment,we observed the adverse reactions and gave the symptomatic treatment.Results The rates of adverse reactions such as hypertension,renal toxicity,oral mucositis,myelosuppression,gastrointestinal reactions,nasal bleeding, abnormal liver function,and hand-foot skin reaction were 60.0%,70.0%,90.0%,100.0%,85.0%,10.0%,45.0%and 25.0%respectively.After symptomatic treatment,all completed the treatment.Conclusions The incidence rate of adverse reactions of famitinib malate combined with radiotherapy and chemotherapy for treating advanced nasopharyngeal carcinoma is high.Close monitoring and observation during treatment courses can ensure the successful completion of treatment.