Efficacy and safety of perioperative application of ambroxol in lobectomy for protecting pulmonary function
10.3760/cma.j.issn.1008-6706.2014.20.034
- VernacularTitle:肺叶切除围术期应用氨溴索保护肺功能的效果及安全性分析
- Author:
Yingming XIANG
- Publication Type:Journal Article
- Keywords:
Ambroxol;
Lobectomy;
Pulmonary function;
Safety
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(20):3129-3130,3131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of perioperative application of ambroxol in lobectomy for protecting pulmonary function,in order to provide reference for clinical treatment.Methods 684 patients who received lobectomy operation were selected ,they were randomly divided into the control group (358 cases) and therapy group(326 cases).Patients of control group were treated with regular therapies ,while patients of therapy group were treated with ambroxol(10mg· kg-1· d-1).Pulmonary function,SOD,PAF,SP-A,complications were compared between the two groups .Results Before treatment ,FVC and FEV1 between the two groups had no significant differ-ences(P>0.05);FVC and FEV1 in the two groups decreased after treatment ,but the control group decreased more significantly (t=5.993,P=0.017;t=5.493,P=0.021);48h after the surgery,SOD,PAF,SP-A of therapy group were (1 259.23 ±320.43)μg/L,(11 521.38 ±2 193.43) mu/mL,(206.38 ±9.22) ng/L,which were better than those of the control group(t=8.329,P=0.001;t=4.394,P=0.025;t=6.943,P=0.008).The incidence rate of complication in therapy group was 8.10%,which was significantly lower than 20.55% in the control group (χ2 =8.932,P=0.000).Conclusion Ambroxol has better efficacy and safety in lobectomy perioperation for protecting pulmonary function ,and its anti-inflammatory performance is better .
