Yikunning Granules Combined with Tibolone and Paroxetine in the Treatment of 75 Cases of Menopausal Syndrome
- VernacularTitle:益坤宁颗粒联合替勃龙、帕罗西汀治疗更年期综合征75例
- Author:
Weibing LI
- Publication Type:Journal Article
- Keywords:
Yikunning granules;
Tibolone;
Paroxetine;
Menopausal syndrome;
Kupperman score;
Hormone level
- From:
China Pharmacist
2014;(9):1536-1537,1538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical effect and safety of Yikunning granules combined with tibolone and paroxetine in the treatment of female patients with menopausal syndrome. Methods:Totally 150 female patients with menopausal syndrome were randomly divided into the control group (75 cases) and the study group (75 cases). The control group was orally given tibolone (2. 5mg,po,qd) and paroxetine tablets (20mg,po,qd), and the study group was treated with Yikunning granules additionally (3g,po,tid). After 3-month treatment, the modified Kupperman score was used to evaluate the clinical symptoms, radioimmunoassay was used to detect the serum lev-els of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) and progesterone (P), and the adverse reactions were recorded. Results:After the treatment, most of the indices in the modified Kupperman score were improved in the two groups (P<0. 05). In the study group, such symptoms as hot flashes and perspiration, anxiety, depression and palpitations, and the general score were improved more notable than those in the control group(P<0. 05). After the treatment, serum levels of E2 was in-creased, while FSH and PRL were decreased(P<0. 05), and PRL and P were unchanged (P>0. 05). The improvement of E2, LH and FSH in the study group was better than that in the control group (P<0. 05). There was no significant difference in the adverse reactions between the two groups (P<0. 05). Conclusion:Yikunning granules combined with tibolone and paroxetine show good effectiveness in the treatment of menopausal syndrome with improved clinical symptom and sex hormone levels, which is worthy of promotion.
