Effects of Total Saponins of Panax Ginseng Combined with Icariin on Learning, Memory and Apoptosis of Hippocampal Neural Cells in Vascular Dementia Rats
- VernacularTitle:人参总皂苷联合淫羊藿苷对血管性痴呆大鼠学习记忆及海马神经细胞凋亡的影响研究
- Author:
Caixia ZHENG
;
Xiping LI
;
Liping CHEN
- Publication Type:Journal Article
- Keywords:
Total saponins of panax ginseng;
Icariin;
Oxygen free radical;
Hippocamus
- From:
China Pharmacist
2014;(9):1444-1446,1447
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of total saponins of panax ginseng ( TSPG) combined with icariin ( ICA) on learning and memory capability, oxygen free radical and apoptosis of hippocampal CA1 pyramidal cells in vascular dementia ( VD) rats. Meth-ods:The VD rats were obtained by occlusion of bilateral common carotid artery and reperfusion repeatedly combined with intraperitoneal injection of sodium nitroprusside. Spacial learning and memory ability was evaluated by 8-arm radial electric maze test on the 21st day af-ter the drug treatment, the activity of SOD and the level of MDA in the brain were determined, and the adjacent sections were used to de-tect fragmented DNA in apoptotic cells( TUNEL) . Results:The learning and memory ability of the model rats judged by the 8-arm radial electric maze test was significantly decreased compared with that in the sham-operated group (P <0.05). The combination treatment could significantly protect and improve all the evaluated indices of the model rats after the 3-week treatment (P<0. 05) with increased SOD (P<0. 05), and decreased MDA (P<0. 01) and TUNEL positive cells (P<0. 05). Conclusion:The combination drug treatment can significantly protect and improve the spacial learning and memory ability of VD rats, which is related with such effects as improving oxygen free radical metabolism and nerve cell injure in hippocampal CA1 region.
