Improvement of Determination Method for Residual Organic Solvents in Olsalazine Sodium
- VernacularTitle:奥沙拉秦钠残留溶剂测定方法的改进
- Author:
Zhan SHU
;
Chengshuai WANG
;
Lanjun ZHENG
;
Binbin YING
- Publication Type:Journal Article
- Keywords:
Olsalazine sodium;
Residual organic solvent;
Headspace GC
- From:
China Pharmacist
2014;(9):1588-1589,1590
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the determination method for the residual solvents in olsalazine sodium. Methods:1,2-Dichlo-roethane and chloroform were determined by headspace GC with a DB-624 capillary column and an FID detector. The column tempera-ture was 110℃. The temperature of the injector and the detector was 200℃ and 250℃, respectively. The carrier gas was nitrogen with a flow of 3. 0 ml·min-1 . The split ratio was 1∶1. Water was used as the solvent. Results:1,2-Dichloroethane and chloroform were completely separated with good linearity within the respective range of 0. 25-2. 52 ( r =0. 999 5 ) and 2. 28-22. 84 μg · ml-1 ( r =0. 999 5). The average recoveries were 98. 4% and 99. 5% with RSD of 1. 14% and 0. 98%(n=9), respectively. The detection lim-it were 0. 02 and 0. 06 μg·ml-1 , respectively. Conclusion:The method is rapid, sensitive and accurate, which can be used in the determination of residual organic solvents in olsalazine sodium.
