A study on the change of matrix metalloproteinase-2 and peripheral white blood cells of acute cerebral in-farction patients at different altitudes
10.3936/j.issn.1002-0152.2014.07.007
- VernacularTitle:不同海拔地区急性脑梗死患者基质金属蛋白酶-2和周围血白细胞计数变化
- Author:
Li MEI
;
Shizheng WU
;
Shukun ZHANG
- Publication Type:Journal Article
- Keywords:
Elevation;
Acute cerebral infarction;
Matrix metalloproteinases-2;
White blood cell count
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(7):414-418,428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the serum levels of matrix metalloproteinase- 2 (MMP-2) and peripheral blood leukocytes content and its relationship with the severity of cerebral infarction in acute cerebral in-farction(ACI)patients at different altitudes (high, middle and low). Methods One hundred thirty-nine cases and 150 healthy controls were included in the present study. Enzyme linked immunosorbent method was used to detect MMP-2 and WBC levels. Results MMP-2 levels increased as the altitude increased in controls. The MMP-2 in a descending or-der was 1.41±0.39 in Haixi (high altitude), 1.37±0.27 in Xining (middle altitude) and 1.28±0.21 in Sichuan (low altitude) (P<0.05). The serum levels of MMP-2 were significantly increased at 7 d at different altitudes (5.75±1.19, 5.23±1.12 and 4.15 ± 0.97 in low, middle and high altitudes, respectively). The WBC were significantly increased at different alti-tudes (12.93±2.11, 12.11±1.74 and 11.15±1.68 in low, middle and high altitudes, respectively) within 48 h in severe ACI group (P<0.05). MMP-2 levels in different altitudes were positively associated with the infarction size and the degree of neurological deficit, while were negatively correlated with the prognosis. The WBC in large infarction group were positive-ly correlated with the infarct size. Conclusions The levels of MMP-2 and WBC in different altitudes may be helpful in determining the ACI lesion size and the severity of the illness as well as estimating the prognosis.
