Meta analysis on value of LMP-1 gene in diagnosing nasopharyngeal carcinoma
10.3969/j.issn.1673-4130.2014.16.006
- VernacularTitle:潜伏膜蛋白1基因对鼻咽癌诊断价值的 meta 分析
- Author:
Ziyuan JIANG
;
Yueming ZHANG
;
Yixi BAO
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma;
latent membrane protein;
diagnosis
- From:
International Journal of Laboratory Medicine
2014;(16):2135-2136,2138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic value of the latent membrane protein 1(LMP-1)gene detection for diagnosing na-sopharyngeal carcinoma(NPC).Methods The related researches on the detection of LMP-1 gene in the nasopharyngeal swab secre-tion for diagnosing NPC by PCR were entirely collected by using the computer retrieval or manual inquiring.Two estimators screened the literature according to the criteria of inclusion and exclusion.The quality evaluation was performed by adopting the QUADAS scale.The heterogeneity test was conducted by using Meta-Disc 1.4 software.According to the heterogeneous character-istics,the corresponding effect model was selected for calculating the pooled sensitivity and specificity and the summary receiver op-erating character(SROC)curve was drawn.Results 139 related articles were retrieved,in which 6 articles were finally included. 394 cases of NPC were definitely diagnosed by the pathological golden standard,802 cases were in the control group.The pooled sensitivity and specificity of the LMP-1 gene for diagnosing NPC were 0.90[95%CI (0.87,0.93)]and 0.98[95%CI (0.96,0.99)] respectively.The area under SROC(AUC)was 0.973 7.Conclusion LMP-1 gene has the higher diagnostic value for NPC and could be used for screening and auxiliary diagnosis of NPC.
