Effects of Kechuanning Capsules on Airway Inflammatory Cells and Infammatory Mediators in Patients with Stable Chronic Obstructive Pulmonary Disease
10.3969/j.issn.1005-5304.2014.09.006
- VernacularTitle:咳喘宁胶囊对慢性阻塞性肺疾病稳定期患者气道炎症细胞及炎性介质的影响
- Author:
Jie SUN
;
Minjuan HAN
;
Xuhui ZHANG
;
Pengpeng CAO
- Publication Type:Journal Article
- Keywords:
Kechuanning capsules;
COPD;
IL-6;
IL-8;
LTB4;
randomized controlled trial
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(9):21-23,24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Kechuanning capsules on airway inflammation cells and inflammatory mediators in patients with COPD.Methods Totally 110 patients with stable COPD were randomly divided into therapy group and control group, 55 cases in each group. Both of the groups were given compound ipratropium bromide solution for inhalation, at the same time, patients in the therapy group took Kechuanning capsules orally, 4 softgels each time, 3 times a day, and patients in the control group took the same amount of placebo capsules. The treatment lasted three months. Differential counting of inflammatory cells and levels of inflammatory factors in serum and sputum supernatant were observed.Results In terms of differential counting of inflammatory cells, the sputum neutrophils of the therapy group decreased significantly (P<0.05) and macrophages increased (P<0.05) after treatment, with statistical significance compared with the control group (P<0.05). In terms of inflammatory mediators, the levels of IL-6, IL-8, LTB4 in serum did not change significantly (P>0.05) in two groups before and after treatment;IL-6, IL-8, LTB4 levels in the sputum supernatant of the therapy group were lower than those before treatment (P<0.05), with statistical significance compared with the control group (P<0.05). Conclusion Kechuanning capsules have an obvious inhibitory effect on airway inflammatory cells in patients with stable COPD as well as the release of inflammatory mediators.
