Correlation between coronary artery disease and levels of glycosylated hemoglobin and endothelin
10.3969/j.issn.1671-8348.2014.24.015
- VernacularTitle:糖化血红蛋白和内皮素变化与冠状动脉粥样硬化的关系
- Author:
Xiujun ZHOU
;
Le HE
;
Yujie LIU
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
diabetes mellitus;
glycated hemoglobin;
endothelin
- From:
Chongqing Medicine
2014;(24):3163-3164,3167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the correlation between coronary atherosclerosis and levels of glycated hemoglobin (HbA1c) and endothelin(ET ) ,furthermore to explore the clinical significance of the two indexes in the department of cardiology .Methods 572 inpatients were divided into four groups according to the blood glucose level and coronary angiography results :negative control group with 40 patients ,simplex DM group with 50 patients ,simplex CHD group with 262 patients ,CHD+DM group with 220 pa-tients .The HbA1c and ET levels in the four groups were monitored ,and the correlations between the two indexes and coronary ath-erosclerosis were analysed by Logistic regression analyses .Results HbA1c level :control group and CHD group < DM group 0 .05) .ET level :control group < CHD group and DM group < CHD+DM group .No significant differences were observed between CHD group and DM group(P>0 .05) .After adjusted the potential risk factors such as age ,sex ,body mass index ,smoking ,the history of hypertension and blood glucose levels with binomial Logistic regression analysis the content of ET was relevant to the onset of CHD ,however HbA1c not .Conclusion ET has obviously correlation with coronary atherosclerosis ,however the simplex DM may cause false posi-tive interferences .Combined determination of HbA1c and ET is beneficial in the preliminary diagnosis of CHD and DM .
