Study of iodine 125 particles implantation combined with high-frequency hyperthermia in the treatment of the advanced lung cancer
10.3969/j.issn.1671-8348.2014.24.028
- VernacularTitle:放射性碘125粒子植入联合高频热疗治疗晚期肺癌的近期疗效观察
- Author:
Xing CHENG
;
Qing LI
;
Qichao XIE
- Publication Type:Journal Article
- Keywords:
advanced lung cancer;
iodine 125 particles;
high-frequency hyperthermia
- From:
Chongqing Medicine
2014;(24):3199-3200,3203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of CT guided implantation of iodine 125 particles combined with high-frequency hyperthermia in the treatment of the advanced lung cancer .Methods From 2011 November to 2013 March ,60 patients with ad-vanced lung cancer were randomly divided into treatment group :high frequency hyperthermia combined with iodine 125 particle im-plantation(30 cases) ,the control group :the iodine 125 particle implantation group(30 cases) .Thermotherapy was performed 3 -5 days after the implantation using NRL-004 type hyperthermia instrument made by Jilin Maida company in China ,every other day once time ,a total of six times ,60 minutes each time .The iodine 125 particle implantation was performed according to the treatment planning system(TPS) formulation by CT guided and the dosage was 90 Gy .The evaluation of treatment effect was conformed by CT scans after two months of treatment .The side effects was assessed too .Results The total effective rate was 96 .7% in the treatment group ,the control group was 80 .0% ,there was a statistically significant difference (P< 0 .05) .The local pain in chest wall remission rate was 75 .0% (6/8) and 50 .0% (5/10) in the treatment group and the control group(P>0 .05) .The side effects of the treatment was slight including pneumothorax and particle migration and so on .Conclusion Iodine 125 particles implantation is an effective treatment in the treatment of advanced lung cancer and can obtained better effects combined with high-frequency hy-perthermia .The side effects of the treatment is slight for two groups and no death related treatment .
