Clinical observation of Rt-PA intravenous thrombolysis for the treatment of acute ischemic stroke
10.3760/cma.j.issn.1008-6706.2014.s1.010
- VernacularTitle:重组组织型纤溶酶静脉溶栓治疗急性缺血性脑卒中的临床观察
- Author:
Damin WANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Thrombolytic therapy;
Tissue plasminogen activator
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(z1):24-25,26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the recombinant tissue type fibrinolytic enzyme ( rt-PA) intravenous throm-bolysis treatment the clinical curative effect of acute ischemic stroke .Methods Will appear symptoms of acute ische-mic stroke(<4.5 hours)patients,76 cases were randomly divided into the two groups according to the envelope meth -od,38 cases in each group .Thrombolysis group was given rt-PA 0.9mg/kg,maximum dose of 90mg;10%of the total dose intravenous injection ,pushing injection time>1 minute,the remaining 90%of the dose required intravenous drip within 1h.Thrombolysis in 24 hours,not the use of anticoagulants or aspirin .After such as clinical and head CT shows no bleeding,review of the available antiplatelet and/or anticoagulant therapy.Control group used aspirin oral,lamps take injection and static drop treatment ,cytidine diphosphate choline course of 14 days.All cases of application of mannitol,symptomatic treatment for patients with complications .Then observation on admission and treatment 1,7,21 days after the NIHSS score .Results Thrombolysis group 1,7,21 days NIHSS score significantly reduced ,each was (11.3 ±3.6)points,(9.1 ±2.8)points,(8.3 ±3.9)points,Degree of neurologic deficits and daily life activities a-bility increased significantly(P<0.05)were 93.3%,93.3%and 93.3%,There was no statistically significant differ-ence incidence and case fatality rate of adverse events (P>0.05),each was 6.7%,6.7%,3.3%.Conclusion Rt-PA intravenous thrombolysis for acute ischemic stroke effect significantly ,can significantly shorten the course of the disease,reduce morbidity,improve the quality of life of the patients .
