Influence of hippophae rhamnoides on neuropeptide Y,gastric emptying and body fat in children with func-tional dyspepsia
10.3760/cma.j.issn.1008-6706.2014.17.002
- VernacularTitle:沙棘对功能性消化不良患儿神经肽 Y、胃动力及体脂的影响
- Author:
Mantian XIAO
;
Xiaoshan QIU
;
Yongyi CAI
- Publication Type:Journal Article
- Keywords:
Hippophae;
Dyspepsia;
Neuropeptide Y;
Gastric emptying;
Adipose tissue;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(17):2564-2566,2567
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hippophae rhamnoides on the level of plasma appetite factors neuropeptide Y ,the gastric motility and on their body fat in children with functional dyspepsia .Methods A hundred and twenty children with functional dyspepsia were simple random sampled divided into the three groups :Group Ⅰ( treated with hippophae rhamnoides ) ,Group Ⅱ( treated with domperidone ) , and Group Ⅲ( treated with hippophae rhamnoides plus domperidone ) .The treatment lasted for eight weeks .The level of plasma neuropeptide Y ( NPY) were measured before and after treatment .All patients underwent a gastric emptying ( GE) test by ultrasound ( US) to measure the rate of postprandial gastric antrum residual ,at 30min,60min,90min and 120min.The average value of subcutaneous fat,body fat percentage,upper arm girth,weight and height were also measured .Results There were no statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢbefore treatment,which were (107.52 ±24.12)ng/L, (114.63 ±17.95)ng/L and(114.56 ±25.10)ng/L(F=1.307,P>0.05).After treatment,there were statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢ,which were (137.38 ±29.86) ng/L,(121.43 ± 13.78)ng/L and (149.27 ±31.9)ng/L.The level of NPY in plasma of groupⅠandⅢwere markedly increased after treatment(t=4.95,5.40,all P<0.05).The postprandial gastric antrum remains in Groups ⅠandⅢwere less than that in group Ⅱat 60 min,90 min and 120 min,respectively(F=4.93,6.40,4.61,all P<0.05).The thickness of skin fold(SF),body fat percentage and upper arm girth and weight in groupⅠand Ⅲ increased more than those in group Ⅱ(F=16.80,46.9,21.06,all P<0.05).The level of plasma appetite factors ,the rate of gastric antrum remaing and SF,body fat percentage,arm girth and weight was similar in groupⅠand group Ⅲ (P >0.05). Conclusion In children′s functional dyspepsia ,the hippophae rhamnoides increases the level of appetite factor neu-ropeptide Y,The child′s body fat increases markedly and physical growth also has obvious improvement .
