The effect of 131 I in the treatment of Graves thyrotoxicosis after long-term use of anti-thyroid drug
10.3760/cma.j.issn.1008-6706.2014.19.008
- VernacularTitle:长期服用抗甲状腺药物对131碘治疗Graves 甲亢效果评价
- Author:
Yanqing SONG
;
Yun ZHU
;
Xuemei HAN
- Publication Type:Journal Article
- Keywords:
Anti-thyroid agents;
Hyperthyroidism;
Graves ophthalmopathy;
Iodine radioisotopes
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(19):2905-2906,2907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of Graves thyrotoxicosis patients treated by long-term use of anti-thyroid drug ( ATD) and without long-term use of ATD ,and to explore the application value and safety of ATD be-fore 131 I treatment.Methods 62 cases with Graves hyperthyroidism were divided into the two groups according to whether received the long-term ATD treatment.The curative effects,hormone level and safety were compared.Results The success rate of ATD group was 43.75%, the success rate of without ATD treatment group was 56.67%, the difference between the two groups had statistical significance (Ridit=15.152,P=0.000).The thyroid mass,FT3, FT4 ,TSH levels after treatment between two groups had no significant differences , but the difference of the highest iodine uptake rate in 24h had significant difference (t =6.954,P<0.05).The adverse reactions in ATD treated group and ATD untreated group were 7 cases(21.88%) and 3 cases(10.00%),there was statistically significant difference between the two groups(χ2 =4.563,P=0.032).Conclusion Long-term ATD therapy before 131I treatment can reduce the highest iodine uptake rate in 24h,reduce the clinical curative effect and increase adverse reaction rate .
