Effect of Shuanghuanglian Combined with Levofloxacin on Antibiotic Resistance of Staphylococcus Aureus ATCC29213 in Rabbit Tissue Cage Infection Model
10.3870/yydb.2014.08.006
- VernacularTitle:双黄连联用左氧氟沙星对兔组织笼感染模型中金黄色葡萄球菌ATCC29213耐药性的影响
- Author:
Guojun WANG
;
Yun YE
;
Bimin FENG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Shuanghuanglian;
Levofloxacin;
Staphylococcus aureus;
Antibiotic resistance;
Model,rabbit tissue cage infection
- From:
Herald of Medicine
2014;(8):1001-1003,1004
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effects of shuanghuanglian combined with levofloxacin on antibiotic resistance of Staphylococcus Aureus ATCC29213 to levofloxacin. Methods Tissue cage infection model with Staphylococcus aureus was established in rabbits, and the infected animals were given with levofloxacin alone ( group A ) or in combination with shuanghuanglian ( group B) for 5 days respectively. Steady-state concentration of levofloxacin in tissue cage, bacteria recovery and bacterial resistance in tissue cage infection model were studied. Results Steady-state concentration of levofloxacin in tissue cage was not significantly different between group A and group B. The recovery rate of bacteria was significantly lower in group B than in group A (20. 0% vs. 100. 0%). The minimum inhibitory concentration (MIC) was lower in group B than in group A. Conclusion Shuanghuanglian combined with levofloxacin is helpful to reduce antibiotic resistance of Staphylococcus aureus to levofloxacin, indicating that some Chinese traditional medicine combined with antibiotics can reduce antibiotic resistance.
