Clinical value of serum tumor marker in early diagnosis ovarian cancer
10.3969/j.issn.1000-484X.2014.08.021
- VernacularTitle:血清肿瘤标志物在卵巢癌早期诊断中的临床价值
- Author:
Juanjuan HOU
;
Shuyan HU
;
Tingting LIU
;
Ling ZHANG
;
Weiyue XI
;
Hongjun ZHENG
;
Yunyan PAN
- Publication Type:Journal Article
- Keywords:
Tumor marker;
Ovarian cancer;
Early diagnosis
- From:
Chinese Journal of Immunology
2014;(8):1101-1104,1107
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the value of serum human epididymis protein 4(HE4),cancer embryonic antigen(CEA), carbohydrate antigen(CA125,CA19-9,CA153),alpha fetoprotein(AFP) and β-human chorionic gonadotrophin (β-HCG) in ovarian cancer early diagnosis.Methods:Abbott Architect i2000SR was used to detect the levels of preoperative serum tumor markers (n=7) in ovarian cancer group,benign ovarian tumor group and the normal control (each n=60).Results:The levels of serum HE4,CA125, CA199,CEA,CA153,AFP and β-HCG in ovarian cancer group were markedly higher than the benign ovarian tumor group and the control group.There was statistically significant difference ( P<0.05 ).The diagnosis of ovarian cancer tumor markers were high specificity,but sensitivity was not high except HE4 (76.67%) and CA125 (68.33%).With Youden Index,the area under curve of ROC,the HE4 was demonstrated higher specificity ,sensitivity and accuracy.There was also medium diagnostic value of CA 125 ,CA199 and CEA for ovarian cancer.The sensitivity of ovarian cancer diagnosis is raised by combined assay with serum tumor marker ,but the specificity would be reduced accordingly.HE4, CA125, CA199 and CEA combined detection is considered the best.Conclusion:CA153,AFP and β-HCG have lowered diagnosis for ovarian cancer.HE4, CA125, CA199 and CEA combined detection could significantly improve specificity ,sensitivity and accuracy in the early diagnosis of ovarian cancer.
