Research progress in reprogramming induced pluripotent stem cells
10.3969/j.issn.1000-4718.2014.07.012
- VernacularTitle:重编程诱导多功能干细胞的研究进展
- Author:
Xiaoling GUO
;
Qing LIU
;
Chan WANG
;
Yonglong GUO
;
Rongjie YU
;
Jiansu CHEN
- Publication Type:Journal Article
- Keywords:
Induced pluripotent stem cells;
Safety;
Efficiency
- From:
Chinese Journal of Pathophysiology
2014;(7):1218-1222,1227
- CountryChina
- Language:Chinese
-
Abstract:
Induced pluripotent stem cells ( iPSCs) have been first induced from mouse fibroblasts since 2006, and the research on iPSCs has made great progress in the following years .iPS cell lines were established from different so-matic cells through DNA , RNA, protein, and small molecule compounds and various methods of transduction , making the induction of iPSCs more secure and effective , and more attractive prospect of clinical application .In this review , different somatic cell reprogramming , different levels of reprogramming , different transduction pathways , and prospect of application are discussed .
