Effect of simulated 400 m He-O2 saturation diving on oxidative-antioxidative system in lungs of rats
10.7644/j.issn.1674-9960.2014.07.005
- VernacularTitle:模拟400 m氦氧饱和潜水对大鼠肺氧化与抗氧化系统的影响
- Author:
Tao YANG
;
Zhiqiang HUANG
;
Ci LI
;
Jia HE
;
Haiting CHEN
- Publication Type:Journal Article
- Keywords:
He-O2 saturation diving;
oxidative stress;
rat;
antioxidative defense
- From:
Military Medical Sciences
2014;(7):493-494,498
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of simulated 400 m He-O2 saturation diving on the pulmonary oxidative-antioxidative system in rats.Methods SD rats were exposed to 4.1 MPa He-O2 mixture for 24 h in an animal chamber. Normal air pressure was used in the control group .The histopathology , contents of malondialdehyde ( MDA) , 8-hydroxy-2′-deoxyguanosine(8-OHdG),and glutathione(GSH) and activities of superoxide dismutase (SOD) and glutathione peroxi-dase( GSH-Px) in pulmonary tissues were determined .Results No difference was found during pathological examination or in MDA, 8-OHdG and SOD activity.GSH and GSH-Px activity were decreased significantly (P<0.05) after hyperbaric exposure.Conclusion Exposure to 4.1 MPa He-O2 for 24 h may promote oxidative stress and reduce antioxidative capacity rather than cause obvious oxidative damage in rat lungs .
