Environmental safety threshold of commonly encountered highly pathogenic microor-ganisms
10.7644/j.issn.1674-9960.2014.07.011
- VernacularTitle:常见高致病性病原微生物环境安全临界值研究
- Author:
Feng DING
;
Shibei LI
;
Zhanbo WEN
;
Cuijuan HU
- Publication Type:Journal Article
- Keywords:
pathogenic microorganisms;
safety threshold;
protection zone;
exposure dose;
environmental risk
- From:Military Medical Sciences
2014;(7):514-517,522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study environmental safety reference standard values of commonly encountered pathogenic microorganisms, and provide the basis for environmental risk assessment of a high-level biosafety laboratory (BSL).Methods Using human exposure dose calculation methods as the basic principle in combination with microbial hazard evaluation methods , an infectious dose calculation model of human exposure to pathogenic microorganisms by breathing was proposed . Based on research on characteristics of commonly encountered pathogenic microorganisms at home and abroad , the environ-mental safety threshold reference standard and environmental risk protection zone for such microorganisms were obtained . Results An the environmental risk assessment standard calculation method for commonly encountered highly pathogenic microorganisms was proposed , and the minimum infectious dose and environmental safety threshold of seven commonly encountered pathogenic microorganisms were obtained , including SARS coronavirus , highly pathogenic avian influenza virus, Mycobacterium tuberculosis, Bacillus anthracis, Yersinia pestis,Francisella tularensis, and epidemic hemorrhagic fever virus.Conclusion The results can be used as a reference standard of infectious aerosols in a high-level BSL for environ-mental risk assessment , laboratory risk control and emergency management .
