Role of the Nrf2 pathway in liver diseases
10.3760/cma.j.issn.1673-4408.2014.05.003
- VernacularTitle:Nrf2抗氧化通路与肝脏疾病的研究进展
- Author:
Lifang ZHOU
;
Shuangjie LI
- Publication Type:Journal Article
- Keywords:
Nrf2;
Oxidative;
Hepatic disease
- From:
International Journal of Pediatrics
2014;(5):462-464,465
- CountryChina
- Language:Chinese
-
Abstract:
Nrf2 signaling pathway is a major mechanism in the cellular defense against oxidative or electrophilic stress,which regulates series of detoxifying and antioxidant defense genes expression in the liver. The Nrf2 signaling pathway collectively exhibits diverse biological functions against viral hepatitis,alcoholic and nonalcoholic liver disease,fibrosis,and cancer via target gene expression. This review discusses the role of the Nrf2 pathway in liver pathophysiology and the potential application of Nrf2 as a therapeutic target of prevention and treatment of liver diseases.
