Kv7 channels in modulation of central monoaminergic neurotransmission
10.3969/j.issn.1001-1978.2014.10.005
- VernacularTitle:Kv7（KCNQ）钾离子通道对中枢单胺能神经传递的调控
- Author:
Chen ZHAO
;
Hailin ZHANG
- Publication Type:Journal Article
- Keywords:
Kv7 channel;
KCNQ gene;
monoaminergic neuro-transmission;
Retigabine;
neuron;
excitability;
disease
- From:
Chinese Pharmacological Bulletin
2014;(10):1350-1352,1353
- CountryChina
- Language:Chinese
-
Abstract:
The KCNQ gene family encodes five Kv7 channel sub-units(Kv7. 1-5) and four of these (Kv7. 2-5) channels are ex-pressed in the central nervous system ( CNS ) . Neuronal Kv7 channels participate in both pre-and post-synaptic modulation of neurotransmissions. Activation of neuronal Kv7 channels inhibits neuronal excitability and limits the release of monoaminergic neu-rotransmitter. Kv7 channel openers provide novel therapeutic op-tions in the treatment of disease states characterized by overactiv-ity of monoaminergic neurons ( e. g. schizophrenia, anxiety and drug abuse) . This review summarizes the studies on expression and functional role of Kv7 channels in monoaminergic neurotrans-mission in the CNS and the potential therapeutic effect of Kv7 channel openers on the disease characterized by overactivity of monoaminergic neurons.
