The correlation between chronic infection of microorganism and the severity of coronary artery disease
10.3969/j.issn.1673-4130.2014.18.015
- VernacularTitle:微生物慢性感染与冠状动脉病变程度的相关性研究
- Author:
Yunfeng SHEN
;
Hongbo ZHANG
;
Yuangui HU
- Publication Type:Journal Article
- Keywords:
Chlamydia pneumonia;
Helicobacter pylori;
human cytomegalo virus;
coronary artery lesion
- From:
International Journal of Laboratory Medicine
2014;(18):2457-2458,2461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between chronic infection of three microorganism and coronary artery lesion by detecting their antibodies and high-sensitivity C-reactive protein(hs-CRP) .Methods According to their severity of coronary artery lesion ,patients enrolled in the study were divided into 4 groups ,including normal control group(n=37) ,single-branch lesion group (n=36) ,double-branch lesion group(n= 30) and multi-branch lesion group(n= 29) .Serum Chlamydia pneumonia IgG(CPN-IgG) ,Helicobacter pylori IgG(HP-IgG) ,human cytomegalo virus IgG (HCMV-IgG) and hs-CRP tests were performed .Results CPN-IgG ,HP-IgG ,HCMV-IgG positive rates and the mixed infection positive rates increased sequentially from normal group to multi-branch group .There were significant differences of CPN-IgG ,HP-IgG ,HCMV-IgG and hs-CRP contents among the 4 groups (P<0 .05) .Logistic analysis showed that CPN-IgG ,HP-IgG and HCMV-IgG were dangerous factors to coronary artery lesion . Conclusion Chronic infections of three microorganism might affect the development of coronary artery lesion .
