The expression and clinical significance of ATM protein in early esophageal squamous carcinoma
10.3969/j.issn.1673-4130.2014.18.003
- VernacularTitle:ATM 蛋白在早期食管鳞癌组织中的表达及意义
- Author:
Wei FAN
;
Xiao HAN
;
Jinyou QI
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma;
ATM protein;
early diagnosis;
immunohistochemistry
- From:International Journal of Laboratory Medicine
2014;(18):2430-2431,2434
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study expression differences of the ataxia telangiectasia mutated (ATM ) protein in early esophageal squamous cell carcinoma tissues and adjacent normal tissues in order to explore its diagnostic significance for early esophageal squa-mous cell carcinoma .Methods ATM protein expression was detected in early esophageal squamous cell carcinoma tissues and adja-cent normal tissues by immunohistochemical SP method and the differential expression was calculated by using statistical methods . Results The positive positive expression rate of ATM protein in the early esophageal squamous cell carcinoma tissue and adjacent normal tissue were 65% and 95% respectively ,which were statistically different (P= 0 .044) .Conclusion The ATM protein ex-pression in esophageal squamous cell carcinoma tissue declined .The detection of ATM protein in esophageal squamous cell carcino-ma tissue could become a reliable method for early diagnose of esophageal squamous cell carcinoma .
