Study on the relationship between type 2 diabetes peripheral neuropathy and the activity of serum superoxide dismutase
10.3969/j.issn.1673-4130.2014.18.013
- VernacularTitle:2型糖尿病周围神经病变与血清超氧化物歧化酶活性的关系
- Author:
Ni GUO
;
Weimin WANG
;
Xin YAN
;
Qingjian SU
;
Meijuan WEI
;
Li YANG
- Publication Type:Journal Article
- Keywords:
diabetic peripheral neuropathy;
oxidative stress;
superoxide dismutase
- From:
International Journal of Laboratory Medicine
2014;(18):2453-2454,2456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between type 2 diabetes peripheral neuropathy and the activity of serum super-oxide dismutase(SOD) ,and the relationship between the activity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabetes peripheral neuropathy .Methods One hundred and twenty-five T2DM patients with diabetic peripheral neuropathy(DPN) and 125 healthy individuals were enrolled in the study .The pyrogallol autoxidation method were used to deter-mine the the activity of serum SOD ,and then the differences of serum SOD activity were compared between the 2 group of people . The relationship between the activity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabe-tes peripheral neuropathy were analyzed .Results The difference of the activity of serum SOD between type 2 diabetes peripheral neuropathy group and control group was statistically significant (t=7 .798 ,P=0 .000) .There were no differences between the ac-tivity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabetes peripheral neuropathy .The SOD activities in 6 .1-7 .0 mmol/L and ≥7 .0 mmol/L groups were statistically significant (P=0 .034) .Conclusion The activity of serum SOD increase in T2DM patients with DPN .The activity of serum SOD is associated with blood glucose concentrations ,and might increase with elevated blood glucose .
