Intestinal microbiota dysbiosis associated with the development of colon cancer：progress and prospects
10.3969/j.issn.1001-1978.2014.08.003
- VernacularTitle:肠道菌群失调与结肠癌发生发展之间关系的研究进展
- Author:
Sheng WANG
;
Xiaoxing HUANG
;
Pengfei YU
;
Xiaotao XU
;
Yifei WANG
;
Li LIU
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
intestinal flora;
obesity;
dysbiosis;
bacterial trans-location;
metabolism;
colon cancer
- From:
Chinese Pharmacological Bulletin
2014;(8):1045-1048,1049
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal microflora is an important part of the organ-ism, promoting digestion and absorption of nutrients, maintaining intestinal normal physiological function, regulating immune sys-tem. Intestinal microflora maintains steady state under normal conditions, but intestinal microbiota dysbiosis occurs when surrounding environment c hanges, such as age, diet, obesity and other metabolic diseases as well as antibiotics. Many recent studies have found intestinal flora could cause a variety of disea-ses, and colon cancer is closely related with intestinal microbiota dysbiosis. Some researches suggest improving the intestinal flora dysbiosis can reduce the incidence of colon cancer and inhibit the growth and the worsening of colon cancer. However, under-lying mechanisms remain unknown. So this article summarizes the research progress on the development of colon cancer and in-testinal microbiota dysbiosis, in order to provide reference for re-search on intestinal flora and colon cancer treatment.
