Rho-ROCK signaling pathway in inhibition of axonal regeneration in the central nervous system
10.3760/cma.j.issn.1673-4408.2014.04.012
- VernacularTitle:Rho-ROCK信号通路抑制中枢神经轴突再生的研究进展
- Author:
Xiaofeng WANG
;
Jing LIU
- Publication Type:Journal Article
- Keywords:
Central nervous;
Axon;
Regeneration;
Rho-ROCK;
Inhibitor
- From:
International Journal of Pediatrics
2014;(4):380-382,383
- CountryChina
- Language:Chinese
-
Abstract:
The regeneration of neurons are very weak after the central nervous system is injured,the lack of growth factors in the internal environment and the existence of various inhibitors in the microenvironment are main reasons. Rho-ROCK signaling pathway mediates inhibitory signals to prevent regeneration of nerve cells in the central nervous system. In this paper,the advances in the research on biological property and regulation and interventions of Rho-ROCK signaling pathway are reviewed.
