Progress on amphiphilic polysaccharide self-assembly micelle delivery system
- VernacularTitle:两亲性多糖自组装胶束给药系统研究进展
- Author:
Xuefei YAN
;
Ye YANG
;
Dengke YIN
- Publication Type:Journal Article
- Keywords:
amphiphlilic;
natural ploysaccharides;
self-assembly micelle;
drug delivery system
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):175-178,183
- CountryChina
- Language:Chinese
-
Abstract:
Natural polysaccharides are a kind of hydrophilic polymers.By grafting hydrophobic moieties to the polysaccharide backbone,could form self-assembled micelle with core-shell structure in aqueous by undergoing intramolecular or intermolecular association between hydrophobic moieties.The self-assembly micelles of amphiphilic polysaccharides provides a positive outlook for drug delivery systems with biodegradability,low antigenicity,good biocompatibility and so on.This review focus on biological activity of amphiphilic polysaccharide as self-assembly carriers,the principle of self-assembly of polymeric micelles,and the recent progress in hydrophobic modification of natural polysaccharides.
