The clinical application and mechanism of tacrolimus in children with kidney diseases
10.3760/cma.j.issn.1673-4408.2014.04.014
- VernacularTitle:他克莫司在儿童肾脏疾病中的临床应用及作用机制
- Author:
Xiaoming WU
;
Zhengkun XIA
- Publication Type:Journal Article
- Keywords:
Tacrolimus;
Children;
Kidney disease
- From:
International Journal of Pediatrics
2014;(4):386-388,389
- CountryChina
- Language:Chinese
-
Abstract:
Immune factor is one of the main mechanism of children glomerular diseases. Tacrolimus has a strong and effective immunosuppressive action comparing with CsA. In recent years,the curative effect of ta-crolimus in the treatment of children with kidney disease has attracted doctors attention. Tacrolimus in the treat-ment for refractory nephrotic syndrome ( steroid-dependent nephrotic syndrome, steroid-resistent nephrotic syn-drome and the frequent recurrence of glomerular syndrome) has obtained the good effect. This article reviews the application of tacrolimus in nephrotic syndrome,focal segmental glomerular sclerosis,mesangial proliferative glo-merulonephritis,membranous nephropathy,lupus nephritis( LN) in the children with kidney disease.
