Meta analysis of T-SPOT.TB test for diagnosing tuberculous meningitis
10.3969/j.issn.1671-8348.2014.25.012
- VernacularTitle:T细胞酶联免疫斑点法诊断结核性脑膜炎的Meta分析
- Author:
Xiuying MA
;
Yunqing YAO
;
Xuan SHE
;
Qin LONG
;
Chengguo YAN
;
Qingxiu ZHANG
- Publication Type:Journal Article
- Keywords:
T lymphocytes;
enzyme-linked immunosorbent assay;
tuberculosis,meningeal;
Meta-analysis
- From:
Chongqing Medicine
2014;(25):3299-3301,3304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of the T-SPOT.TB test for diagnosing tuberculous meningitis(TBM) by meta-analysis.Methods A systematic retrieval from the databases of PubMed,EMBASE,etc.was performed.The literature on the T-SPOT.TB test for diagnosing TBM was collected.Two reviewers independently screened the literature,extracted the data and judged the quality.The meta analysis was conducted by the Meta-Disc 1.4 software.Results 8 articles were included,involving 425 patients including 232 cases of TBM.In the peripheral blood group,the combined sensitivity was 80%(95%CI:0.74-0.85),the combined specificity was 74%(95%CI:0.67-0.80),the area under the curve(AUC)of summary receiver operating characteristic (SROC)was 0.858 7;the diagnostic odds ratio(DOR)was 15.50.In the CSF group,the combined sensitivity was 76%(95%CI:0.70-0.82),the combined specificity was 83%(95%CI:0.77-0.88),AUC was 0.892 7;DOR was 22.62.Conclusion Adopting the T-SPOT.TB test conduces to increase the diagnostic rate of TBM.The diagnostic accuracy of the T-SPOT.TB test for CSF may be higher than that for peripheral blood.
